XYY syndrome, and XYY-XXYY mosaicism also showing features of Klinefelter's syndrome.
نویسندگان
چکیده
Both the 48,XXYY and the 47,XYY chromosome anomalies are now well-recognized conditions following the first reports by Muldal and Ockey (1960) of the XXYY genotype, and Sandberg et al. (1961) who described an XYY male. This paper presents the findings in 2 patients with 47,XYY/48,XXYY mosaicism, and one patient with the 47,XYY anomaly, discovered among 250 men in a comprehensive hospital for the mentally subnormal in which there are no special security facilities. They had been selected for the investigation because of their outstanding tallness and their histories of antisocial and delinquent conduct in association with mental retardation.
منابع مشابه
A new 48, XXYY/47, XYY syndrome associated with multiple skeletal abnormalities, congenital heart disease and mental retardation
While the XYY and XXYY syndromes have been several time described in patients, the combination of both syndromes in an individual is a rare event and may result in a severe phenotype. In the present observation, a boy with congenital scoliosis due to segmented thoracic hemivertebra associated with radioulnar synostosis and congenital heart disease is described. Chromosome G-banding and FISH ana...
متن کامل48,XXYY syndrome associated with acromegaloidism.
We report a case of double male syndrome, a type of Klinefelter's syndrome with 48,XXYY chromosome, associated with acromegaloidism. Although the patient presented acromegalic appearance, he did not show hypersecretion of growth hormone (GH). GH provocation tests revealed a rather low GH responses or no responses. After testosterone therapy, the GH responses were normalized except to Insulin to...
متن کاملCognitive, Affective Problems and Renal Cross Ectopy in a Patient with 48,XXYY/47,XYY Syndrome
Klinefelter syndrome is the most common sex chromosome abnormality (SCA) in infertile patients and 47,XXY genomic configuration constitutes most of the cases. However, additional Xs and/or Y such as 48,XXYY, 48,XXXY, and 47,XYY can occur less frequently than 47,XXY. Those configurations were considered as variants of Klinefelter syndrome. In this report, we present an infertile man with tall st...
متن کاملpopulations , with a case report . males in two juvenile court Cytogenetic survey of XYY
The XYY anomaly has been recognized since 1961 (Dunn et al, 1961; Sandberg et al, 1961), but in contrast to other sex chromosome aneuploidies, no consistent clinical syndrome associated with it has emerged. The phenotypes are wide ranging, but generally are tall normal males. Most interest in the syndrome has centred on the possibility that abnormal behaviour may be an associated feature. The f...
متن کاملCriminality in men with Klinefelter's syndrome and XYY syndrome: a cohort study
OBJECTIVE To investigate the criminal pattern in men between 15 and 70 years of age diagnosed with 47,XXY (Klinefelter's syndrome (KS)) or 47,XYY compared to the general population. DESIGN Register-based cohort study comparing the incidence of convictions among men with KS and with 47,XYY with age- and calendar-matched samples of the general population. Crime was classified into eight types (...
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ورودعنوان ژورنال:
- Journal of medical genetics
دوره 6 2 شماره
صفحات -
تاریخ انتشار 1969